Article R1221-20-4 of the French Public Health Code
Non-substantial modifications must be declared to the regional health agency. A copy is sent to the Etablissement français du sang or, where applicable, to the Centre de transfusion sanguine des armées. Non-substantial modifications are modifications that are not listed in article R. 1221-20-3 and in particular: 1° The appointment of a new depot manager; 2° The change of equipment appearing on the list of health depot equipment determined by order…